The Ichikawa lab integrates chemical biology, organic chemistry, and chemical proteomics to explore the intricacies of protein modifications and their impacts on biological systems. These modifications are pivotal in virtually every physiological process, acting as crucial components in cellular signaling, and their malfunction can lead to numerous human diseases. We are merging approaches of chemistry and biology to deepen our understanding of protein modifications in human biology and disease, aiming to uncover the underlying mechanisms and establish a foundation for innovative therapeutic strategies.