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Cornell University

The McLafferty Legacy

Fred Warren McLafferty

Fred Warren McLafferty (May 11, 1923 − December 26, 2021) obtained his Ph.D. in Chemistry at Cornell in 1950 and, after post-doctoral work at the University of Iowa, began his pioneering work in mass spectrometry with the Dow Chemical Company. He returned to Cornell in 1968 as a member of the faculty. Fred’s numerous contributions to the field of chemistry include the development of the first Gas Chromatograph/Mass Spectrometer (GC/MS) with Roland Gohlke, the description of a complex chemical rearrangement now known as the “McLafferty Rearrangement”, the characterization of large protein macromolecules by mass spectrometry, and the co-authoring and editing of over 500 articles, five books, and a widely-adopted registry of mass spectral data. A true lion of chemistry, Fred revolutionized the field and inspired scholarship for peers and students alike (Ref).

An interview with Fred McLafferty about his pioneering career in mass spectrometry.

Focus in Honor of Fred McLafferty, 2003 Distinguished Contribution Awardee, for the Discovery of the “McLafferty Rearrangement.”